49 - Freie Mitteilung
Clinical works II
16. Mai 2019, 10:15 - 11:45, Bellavista 2, 6. OG


Comparison of intrapleural use of urokinase and t-PA/DNase in pleural infection
B. Bédat, J. Plojoux, J. Noel, A. Morel, J. Worsley, F. Triponez, W. Karenovics, Presenter: B. Bédat (Geneva)

Fibrinolysis can be used to improve fluid drainage in pleural infection. Treatment with either urokinase or tissue plasminogen activator (t-PA) in association with deoxyribonuclease (DNase) via a chest tube has been effective at reducing the need for surgery. This study is the first to compare the efficacy of these two treatments.
We performed a single-centre controlled prospective cohort study. All individuals with pleural infection admitted to our hospital between January 2014 and December 2017, who were treated with antibiotics, a chest tube, and fibrinolysis, were included in this study. The rate of additional procedure requirements (additional chest tube or surgery) after initial fibrinolysis, complications, costs, and radiological and biological outcomes were analysed.
Among the 93 patients included in this study, 34% experienced additional procedure after an initial fibrinolysis, including 21% who received an additional chest tube and 13% who underwent thoracoscopy. The need for additional procedure arose due to presence of multiple pleural collections (P = 0.01) and was associated with the use of large-bore drain (P = 0.01). The success rate of fibrinolysis was not significantly different between urokinase and t-PA/DNase (P = 0.35). The difference in drainage duration and in length of hospital stay were not significant as well (P = 0.05 and P = 0.12, respectively). Treatment with t-PA/DNase was cheaper (P = 0.04) but was also associated with a higher rate of haemothorax (P = 0.002).
In conclusion, treatment with urokinase is safer and equally effective when compared with treatment with t-PA/DNase.
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